The laboratory of Joshua Goldhaber, MD, Director of Basic Research Programs at the Smidt Heart Institute at Cedars-Sinai Medical Center in Los Angeles, has an opening for a Research Associate I to pursue basic and translational studies of cardiac function. The goal of this National Institutes of Health-funded research is to study fundamental mechanisms regulating contractility and pacemaker activity in cardiac cells in genetically modified mice and also in animal models of disease. These discoveries will lead to new therapies for patients. Many previous dedicated laboratory staff have gone on to receive higher degrees in Medicine, Science and Pharmacy.
Working under direct supervision, our Research Associate I will perform PCR, isolation of DNA and synthesis of RNA, Western Blots, immunostaining, fluorescence microscopy, buffer preparation, breeding of genetically modified mouse lines, identification of genetic markers, rodent echocardiography, ordering laboratory supplies and animals, isolating cardiomyocytes from small animals, data analysis, statistical analysis, figure and manuscript preparation. Will perform a variety of routine experimental protocols and procedures to support the objectives of one or more laboratory research projects in a specific area of research. Assists in general laboratory activities, including maintenance of reagents and stocking of supplies, files and monitors documents and keeps accurate and detailed records of experiments and results. Will assist in the operation of specialized equipment and machinery and will be expected to observe all safety standards and procedures. You will be able to perform routine cellular, micro- and molecular biology procedures including, but not limited to Western, Northern blot, DNA/RNA, PCR, protein extraction, cell culture, Immunohistochemistry, and staining. This position does not have supervisory responsibilities.
Essential job duties and responsibilities:
Performs a variety of routine laboratory tasks and procedures.
Keeps accurate and detailed project records of experiments and results.
May assist with animal husbandry.
Maintains lab equipment and related records.
Transports, processes and logs samples.
Maintains computer database with relevant clinical information.
Performs lab maintenance duties, including glassware cleaning and sterilization.
Maintains stocks of general lab materials, and places orders for lab equipment and supplies.
Assists new students and fellows at the laboratory.
Assists in the operation of specialized equipment and machinery.
Observes and complies with safety standards and procedures.
Bachelor of Science or Bachelor of Arts Degree in biological sciences is required
Molecular biology, biochemistry, physiology or equivalent preferred
The successful candidate will be highly motivated and well-organized with outstanding communication and documentation skills, and ability to work independently.
Candidates with substantial basic laboratory experience are preferred.
Understanding of general research objectives.
Working knowledge of database management, personal computers, and presentation and imaging software.
Understanding of general research objectives.
Familiar with routine laboratory procedures and experimental protocols.
Must possess computer skills to include, but not limited to, Excel and Word.
Working Title: Research Associate I - Smidt Heart Institute - Goldhaber Lab
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.