Post-Doctoral Associate position is available in the laboratory of Dr. Jin O-Uchi at the Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis MN (https://www.heart.umn.edu/). O-Uchi lab is seeking one highly motivated Post-Doctoral Associate with an interest in cardiac ion channel physiology and mitochondrial biology. Our research aims to explore the detailed mechanism underlying the cardiac excitation and contraction/metabolism coupling by Ca2+ ion in the normal and disease hearts. Specifically, we are investigating the significance of adrenergic signaling in heart and its regulation of cardiac ion channel/transporters. The research projects at O-Uchi lab are currently supported by, NIH/NHLBI, AHA, and other private foundations.
The interdisciplinary LHI is home to scientists, physician-scientists and students investigating molecular mechanisms of cardiac disease, with focal areas in cardiac regenerative medicine, cardiac hypertrophy and failure, ischemia/reperfusion, arrhythmias and sudden cardiac death.
35% Designing & Conducting Experiments The Post-Doctoral Associate will be expected to study the role of adrenergic signaling on mitochondrial Ca2+ influx mechanism in the normal and disease hearts using novel mitochondria-targeted biosensors for Ca2+, ATP, and ROS measurements. The candidate will have unique opportunities to carry out interdisciplinary research, which cover cardiac physiology, molecular biology and ion channel biophysics to address biologically and clinically significant questions.
35% Collaborate, Implement, and Analyze Experiments Utilize multidisciplinary techniques such as gene transfer, Western blot, patch clamping and confocal imaging are routinely applied to isolated cardiac mitochondria, single live cells, tissues, and in vivo preparations.
30% Documenting Experimental Data Maintain detailed documentation of procedures and experimental data is expected. This involves analyses of data, writing summary reports on results of work and discussing results with laboratory colleagues and Principal Investigator. Post-Doctoral Associate will be required to present independent review of relevant scientific literature for ongoing projects and discussions of possible new experimental approaches with laboratory colleagues and principal Investigator. In addition, you will be required to present regular presentations of scientific data and significant contribution to the preparation of manuscripts.
The University of Minnesota offers a comprehensive benefits package including:
Competitive wages, paid holidays, vacation and sick leave
Low cost medical, dental, and pharmacy plans
Health care and dependent daycare flexible spending accounts
Excellent retirement plans with employer match
Disability and employer paid life insurance
Wellbeing program with reduced insurance premiums
Tuition reimbursement opportunities covering 75%-100% of eligible tuition
Required Qualifications -PhD and/or MD degree; and -Postdoctoral/predoctoral research training in cardiac physiology and/or mitochondrial biology.
Preferred Qualifications -Experience in cardiac electrophysiology, Ca2+ imaging, confocal microscopy, and in vivo cardiovascular disease models -Excellent interpersonal and communication skills, including the ability to publish in English language peer-reviewed journals.
Internal Number: 334366
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